Determination of N-Acetyl-p-Aminophenol in Plasma
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چکیده
منابع مشابه
Determination of n-acetyl-p-aminophenol in plasma.
Two methods for the determination of N-acetyl-p-aminophenol (APAP) in plasma that differ in principle from the diazotization procedure of Brodie and Axelrod (1) are described. One method based on the differential absorption peak of APAP at 266 m, which corresponds to the isosbestic point of common drugs such as acetylsalicylic and salicylic acids, is simple and most specific for APAP. The other...
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There is now ample evidence that the oral administration of aspirin leads to an increase in faecal blood loss in the majority of normal people. Some investigators (Lange, 1957; Alvarez and Summerskill 1958; Stubbe, Pietersen, and Van Heulen, 1962) have used chemical means of testing for occult blood in faeces, and others (Matsumoto and Grossman, 1959; Watson and Pierson, 1960; Holt, 1960; Scott...
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/ / .‘: groups, there were no large differences among them.’ As measured with the bomb calorimeter, the average number of calories per 100 g of dry matter was 585.5 for the 197 samples whereas, calculated from the fat and nitrogen content of the samples, an average of 595.4 was found. Expressing the measured calorie content as 100%, the calculated value was 101.7%. The standard deviation of the...
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A gas-chromatographic procedure for acetaminophen is described in which the drug is chromatographed as the O-heptyl-N-methyl derivative. This derivative is prepared by a sequential alkylation procedure in which the phenolic hydroxyl group of the parent compound is alkylated off-column with heptyl iodide and the amide group is derivatized on-column by reaction with trimethylanilinium hydroxide. ...
متن کاملApplication of Mixed Micelle-Mediated Extraction for Selective Separation and Spectrophotometric Determination of P-Aminophenol Impurity in Pharmaceutical Formulations
A procedure for separation/preconcentration of para-aminophenol (PAP) in pharmaceutical formulation, based on cloud point extraction (CPE) as a prior step to determination by UV-Vis spectrophotometry has been developed. The analyte reacted with 4-dimethylamino benzaldehyde (DAB) in acidic media to form a shift base, which were separated and preconcentrated in a mixed micelle of the anionic surf...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1968
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/14.9.882